AMD Ryzen CPUs and UAD-2 PCIe Compatibility Updated November 03, 2025 10:23 UAD-2 SOLO, DUO and QUAD PCIe cards are incompatible with AMD Ryzen systems. Note: We have not received any reports of compatibility issues between Ryzen CPUs and UAD-2 OCTO PCIe cards. Related to: Compatibility pcie UAD-2 AMD Ryzen